- Directors: Wolfgang Petersen
- Producers: Arnold Kopelson, Anne Kopelson, Wolfgang Peterson, Gail Katz
- Writers: Laurence Dworet, Robert Roy Pool
- Genres: Drama, Sci-Fi, Thriller
- Actors: Dustin Hoffman, Rene Russo, Morgan Freeman, Cuba Gooding Jr, Patrick Dempsey, With Donald Sutherland, And Kevin Spacey
The Motaba virus is discovered in a mercenary camp in Africa in 1967 and kept top secret. Two soldiers order the camp bombed to cover up the discovery of the virus.
Thirty years later, the virus resurfaces in Africa. Col. Sam Daniels (Dustin Hoffman), a USAMRIID virologist is sent to investigate the Motaba case. He and his crew gain information about the virus and return to the United States where he asks his superior, General Ford (Morgan Freeman), to put out an alert for the virus. Ford, who knows the virus is not new, tells Daniels that it is unlikely to show up. Neither of them know that one of the host animals, a White-fronted Capuchin Monkey, has been illegally brought to the U.S. to be sold as a pet. Jimbo Scott (Patrick Dempsey) takes the monkey to Cedar Creek, California. On the trip, the monkey infects Jimbo with the virus.
Once Jimbo arrives at the pet store the owner tells him he got the wrong gender, but only after the monkey has infected him. Jimbo releases the monkey into the woods. Jimbo starts to show signs of infection on his plane trip to Boston, where he gets off the plane and kisses his girlfriend, infecting her. They are both hospitalized and Daniels’ ex-wife, Robby (Rene Russo), investigates the infection. Jimbo, his girlfriend and the pet store owner die from the virus. Robby investigates and concludes that everybody in Boston checked out all right.
On the way back they are confronted by McClintock (who also came by helicopter to prevent them from returning to Cedar Creek). Daniels has Salt fire a missile into the trees to trick McClintock with a decoy helicopter crash. Returning to Cedar Creek, Salt mixes the monkey’s antibodies with the E-1101 to create an anti-serum, in time to save Robby but not Casey. Daniels discovers Operation Clean Sweep is in progress; he and Salt take it upon themselves to fly in the way of the bomber to stop it. With support from Ford, Daniels is able stay in the way of the plane long enough to convince the pilot and his bombardier that information was withheld from them. The bombardier detonates the bomb over water instead of the town. Ford, having had enough of McClintock’s agenda, relieves him of command and places him under arrest for withholding information from the President. McClintock promises to take Ford down with him. Daniels makes up with his wife, and the remaining residents of the town are successfully cured.