- Directors: Stephen Sommers
- Producers: Stephen Sommers, Bob Ducsay
- Writers: Stephen Sommers
- Genres: Action, Adventure, Horror, Fantasy, Thriller
- Actors: Hugh Jackman, Kate Beckinsale, Richard Roxburgh, David Wenham, Shuler Hensley, Elena Anaya, Will Kemp, Kevin J O Connor, Alun Armstrong
The film begins in black and white, set in Transylvania, 1887. Doctor Victor Frankenstein brings to life the Frankenstein’s monster but his triumph is cut short when an angry mob infiltrates the castle. Dr. Frankenstein has been aided in his experiments by his deformed assistant Igor, and Count Dracula. Dracula reveals that he helped Frankenstein so he could use the Monster to bring his undead children to life. He then kills Frankenstein when he refuses to help him. The Monster escapes with his father’s body to a windmill which is burnt down by the mob, the Monster seemingly perishing in the destruction.
A year on, legendary monster hunter Van Helsing hunts Mr. Hyde in Paris, although their confrontation results in Hyde’s death whilst fighting in Notre Dame. Van Helsing returns to the Vatican where he reports to the Knights of the Holy Order, who protect the world from evil. Van Helsing had lost his memory and had been taken in by the monks of the Vatican. Van Helsing’s duty is to defeat evil forces and bring them back to the Order, but he has little success, since he usually kills them, like he did with Mr. Hyde. The leader, Cardinal Jinette, sends him to Transylvania to kill Dracula and prevent the last of the Valerious family from falling into purgatory; the family having been trying to kill Dracula for the past nine generations but all failed and unable to enter Heaven due to an ancestor’s vow. Jinette also gave Van Helsing a torn piece of paper, with a Latin inscription, unknown for its purpose, which reads ‘Deum ac ianuamimbeat aperiri’, in English translates, ‘In the name of God, open this door’. It also had an insignia, which matches the symbol on Van Helsing’s ring. Jinette advises that he might find ‘the answers you seek’. Van Helsing is aided by Carl, a friar who creates inventions.
Anna arrives and injects the cure into Van Helsing, but not before he attacks and kills her. Anna is cremated on a cliff overlooking the ocean, Van Helsing seeing her and her family in Heaven, the family finally at peace. The Monster departs on a raft into the ocean. Van Helsing and Carl depart back to Rome on horseback.