- Directors: Francis Lawrence
- Producers: Gilbert Adler, Michael Aguilar
- Writers: Screenplay, Kevin Brodbin, Frank Cappello, Comic Book, Alan Moore, Jamie Delano, Garth Ennis
- Genres: Action, Fantasy, Horror, Thriller
- Actors: Keanu Reeves, Rachel Weisz, Shia LaBeouf, Tilda Swinton, Pruitt Taylor Vince, Djimon Hounsou, Gavin Rossdale, Peter Stormare, Nicholas Downs
Searching through ruins in Mexico, a young man accidentally finds the Spear of Destiny wrapped in a Nazi flag. Immediately possessed by a supernatural force, he is propelled on a journey to Los Angeles, where he is now seemingly indestructible and causing demonic and unnatural damage as he goes. In Los Angeles, occult detective John Constantine (Keanu Reeves) exorcises a demon from a teenage girl, finding himself unnerved by the demon’s unusually bold attempt at crossing over into humanity’s realm. Later that night, disturbed mental patient Isabel Dodson (Rachel Weisz) commits suicide, provoking the sorrow and disbelief of her twin sister, L.A.P.D. Detective Angela Dodson (Rachel Weisz). Visiting the hospital where Isabel died, Angela encounters Constantine, who is being treated at the same hospital for his terminal lung cancer, a result of his decades-long chain-smoking habit. Disgusted with the prognosis, Constantine visits a nearby church to speak with the angel Gabriel (Tilda Swinton), angrily asking what more he must do to earn God’s forgiveness. Unsympathetic to Constantine’s plight, Gabriel rebuffs his attempts at reconciliation with God, tells him about sacrifices which can be done and then pointing out the selfish undertones beneath his good deeds. Meanwhile at the same church, Angela begs a priest to allow Isabel to receive a church-sanctioned funeral, which the Bishop has refused, pointing out the Catholic rules regarding suicides.
At the end of the film’s credits, Constantine visits Chas’s grave, leaving his cigarette lighter atop the grave. As Constantine turns to leave, Chas appears as an angel, and flies silently into the sky, leaving behind a smiling Constantine.