- Directors: Rob Bowman
- Producers: Chris Carter, Daniel Sackheim
- Writers: Screenplay, Chris Carter, Story, Chris Carter, Frank Spotnitz
- Genres: Adventure, Crime, Horror, Mystery, Sci-Fi, Thriller
- Actors: David Duchovny, Gillian Anderson, Martin Landau, Mitch Pileggi, William B Davis, Blythe Danner, Armin Mueller Stahl
The film opens in 35,000 BC North Texas during prehistoric times in a wordless sequence. A Neanderthal man stumbles upon what appears to be a large, primal, vicious alien in a cave (although the camera work uses zooms and flash-edits to keep the creature from being visualized fully). The two fight, and the caveman wins, stabbing the alien to death. However, fans of the show will recognize the black oil as it bleeds from the alien’s wounds and soaks into the Neanderthal. After a fade to modern-day small-town Texas, a little boy (Lucas Black) falls down a hole in his back yard, and finds a human skull. As he picks it up, black oil seeps out from the ground beneath his feet, and black slivers move up his legs until they reach his head – his eyes go black. Shortly afterward, a team of firemen descend to rescue him. They are presumably lost to the same fate as the boy (it is later said that the four firemen and the boy were all transported). A team of biohazard-suited men in a helicopter, accompanied by several semi-trailers and a man named Ben Bronschweig (Jeffrey DeMunn) descend upon the scene.
At another crop outpost in Tunisia, Strughold is given a telegram by the Cigarette-Smoking Man; the telegram informs them that The X-Files have been reopened.