- Directors: Chris Sanders, Dean DeBlois
- Producers: Clark Spencer
- Writers: Chris Sanders, Dean DeBlois
- Genres: Animation, Adventure, Family, Sci-Fi
- Actors: Daveigh Chase, Chris Sanders, Tia Carrere, David Ogden Stiers, Kevin McDonald, Ving Rhames, Jason Scott Lee
Dr. Jumba Jookiba (David Ogden Stiers) is put on trial by the galactic governing body for illegal genetic experiments, including Experiment 626, an aggressive and cunning creature that is nearly invulnerable. Jumba is imprisonsed while 626 is set to be exiled on an asteroid. However, during transport on Captain Gantu’s ship, 626 escapes to the planet Earth. The Grand Councilwoman orders Jumba to work with Agent Pleakley (Kevin McDonald) to recover 626 discreetly. 626 survives his escape attempt to Earth and lands in Hawaii, but is knocked unconscious by a passing truck, and is taken to an animal shelter believed to be a breed of dog.
After the recent death of their parents in a car accident, 21-year-old Nani Pelekai (Tia Carrere) is forced to take care of herself and her younger, more rambunctious sister Lilo (Daveigh Chase). They are visited by Cobra Bubbles (Ving Rhames), a social worker that warns Nani that if she cannot care for Lilo, he will be forced to take her to foster care. To try to help Lilo relax, Nani allows her to adopt a dog from the animal shelter, and Lilo immediately takes keen interest in 626 despite misgivings from Nani and the shelter. Lilo names 626 “Stitch”, and shows him around the island; Stitch quickly discovers escape is impossible as he cannot swim. Nani is forced to bring Lilo and Stitch with her as she attempts to secure a job, while Lilo uses the time to try to curb Stitch’s aggressiveness by making him behave as Elvis Presley. However, Stitch’s antics, at times foiling Jumba and Pleakley’s attempts to capture Stitch, ruin Nani’s chances. David, Nani’s friend, suggests a day at the beach for the four of them to help relax Nani. While attempting to teach Lilo and Stitch how to surf, Jumba makes one more effort to capture Stitch from underwater; as a result, it appears Stitch attempted to drown Lilo. Though everyone is safe on shore, Cobra saw the whole event and tells Nani he will be by in the morning to collect Lilo. After being chastised by both Nani and Lilo, Stitch leaves on his own, recognizing the importance of family.
Stitch manages to escape his confinement, and with help from Jumba’s ship and by launching a gas tanker truck out of a volcano, he is able to free Lilo and stop Gantu. After they land, they find that the Grand Councilwoman has arrived nearby, escorted by Cobra, to arrest Stitch personally. However, when she sees Stitch hugging Nani and Lilo, she realizes he has become a civilized creature. Using Lilo’s certificate of Stitch’s ownership as proof, the Councilwoman asserts that Stitch is now a part of Nani and Lilo’s family on Earth, and lets him go free. As her guards take Gantu away, she exiles Jumba and Pleakly to Earth, and orders Cobra, a former CIA agent who previously met the Councilwoman at Roswell, to keep an eye on the new family. Lilo becomes integrated into Nani’s and Lilo’s family, and their house is rebuilt with the help of Jumba and Pleakly.