- Directors: Danny Boyle
- Producers: Andrew Macdonald
- Writers: Alex Garland
- Genres: Horror, Sci-Fi, Thriller
- Actors: Cillian Murphy, Naomie Harris, Noah Huntley, Christopher Eccleston, Brendan Gleeson
Late one night, British animal rights activists break into the Cambridge Primate Research Facility to free chimpanzees being used for medical research. The local scientist warns the activists that the chimps are infected with something he only calls “Rage,” but the activists disregard him and set a chimp free. It immediately attacks and infects the activists and scientist.
28 days later, a bicycle courier named Jim (Cillian Murphy) awakens from a coma in a deserted hospital. As he leaves the hospital, he discovers London is completely deserted and rife with signs of catastrophe. Jim is soon discovered and chased through the streets by infected people before being rescued by two survivors, Selena (Naomie Harris) and Mark (Noah Huntley), who rush him to their hideout in the London Underground. They reveal that while Jim was comatose, the virus spread uncontrollably among the populace, turning most people into vicious monsters (“the Infected”) and resulting in societal collapse, possibly on a global scale.
Selena and Mark accompany Jim to his parents’ house, where he discovers that they committed suicide. That night, two of the Infected attack the survivors, and when the fight ends they discover that Mark is bleeding and is likely infected. Selena immediately kills him with a machete, explaining to Jim that infection is spread through the blood and overwhelms its victims in seconds, rendering them deadly to others. She warns that should he become infected, she will kill him “in a heartbeat.” As the two journey through the derelict city the next day, Selena rules out intimacy between her and Jim, declaring that only the fight for survival remains. They discover two more survivors, Frank (Brendan Gleeson) and his teenage daughter Hannah (Megan Burns), holed up in an abandoned block of flats. Invited to spend the night, Selena and Jim privately debate whether they should remain with Frank and Hannah. Jim says they seem like good people, while Selena fears they will slow her down, warning Jim that putting others ahead of one’s own personal survival is a sure way to get killed.
Selena and Hannah rush Jim into a deserted hospital, where Selena performs life-saving emergency procedures. 28 days later, a bandaged Jim is shown waking up in recovery again, this time on one side of a double bed in a remote cottage. Downstairs, he finds Selena sewing large swaths of fabric when Hannah appears. The three rush outside and unfurl a huge cloth banner, adding the final letter to the word “HELLO” laid out on the meadow. As a military jet flies over the landscape, the Infected are shown lying helplessly by the road, dying of starvation. After the jet zooms past the three waving survivors and their distress sign, Selena wonders aloud, “Do you think he saw us this time?”