- Directors: Betty Thomas
- Producers: John Davis, David T Friendly, Joseph Singer
- Writers: Hugh Lofting, Nat Mauldin, Larry Levin
- Genres: Family, Comedy
- Actors: Eddie Murphy, Oliver Platt, Kristen Wilson, Ossie Davis, Norm Macdonald, Chris Rock, Peter Boyle
The film now opens with John Dolittle as a child talking to his dog (voiced by Ellen DeGeneres). He asks his dog questions, one being “Why do dogs sniff each other’s butts”? Her response is that it’s their way of shaking hands. His concerned father (Ossie Davis) hears the question and says that the dog doesn’t have any idea what he said. He was wrong. He finds this out when John meets his new principal and sniffs his butt. The dog obviously knows something is going to happen. When his father hires a minister to remove the evil from him (and freaking him out), the dog saves him by biting the minister. The dog is then taken up for adoption. John is very upset and stops talking to animals as his father teaches him to hate them.
Thirty years later, we see John Dolittle (Eddie Murphy) shooing a puppy out of his apartment. He is a doctor, married with two kids, but became an animal hater. His oldest daughter Charisse (Raven-SymonÃ©) wants to be named Paprika. His youngest daughter Maya (Kyla Pratt) is a nerdy girl who does experiments, such as raising a swan egg (or so she thinks) so it will bond with her. She also has a Guinea Pig named Rodney (voiced by Chris Rock). John’s wife Lisa (Kristen Wilson) also just wants to spend time with him. Meanwhile at work, a big medical company owner named Calloway (Peter Boyle) wants to buy the company. Everyone is very excited because this means much more money.
In the end, John is now a both human doctor and a veterinarian. Maya’s egg hatches, revealing to be an alligator. The rats are mad that the ending is happy, but the owl shows up and chases them away, trying to eat them (luckily, she doesn’t). John and Lucky are seen walking to the circus to visit the tiger and talking about their future as friends, while the song “Talk with the Animals” plays in the background.