- Directors: Edmund Goulding
- Producers: Irving Thalberg
- Writers: William A Drake, Based on the play by Drake and a novel by Vicki Baum
- Genres: Drama, Romance
- Actors: Greta Garbo, John Barrymore, Joan Crawford, Wallace Beery, Lionel Barrymore, Lewis Stone, Jean Hersholt
Doctor Otternschlag (Lewis Stone), a disfigured veteran of World War I and a permanent resident of the Grand Hotel in Berlin, wryly observes, “People come and go. Nothing ever happens,” after which a great deal transpires. Baron Felix von Geigern (John Barrymore), who squandered his fortune and supports himself as a card player and occasional jewel thief, befriends Otto Kringelein (Lionel Barrymore), a meek accountant who, having discovered he is dying, has decided to spend his remaining days in the lap of luxury. Kringelein’s former employer, industrialist General Director Preysing (Wallace Beery), is at the hotel to close an important deal, and he hires stenographer Flaemmchen (Joan Crawford) to assist him. She aspires to be an actress and shows Preysing some magazine photos for which she posed, implying she is willing to offer him more than typing if he is willing to help advance her career.
Another guest is Russian ballerina Grusinskaya (Greta Garbo), whose career is on the wane. She unexpectedly returns from the theatre while the Baron is stealing her jewelry, and when she discovers him in her room she tells him, “I want to be let alone.” Disregarding her, the Baron stays and engages her in conversation, and Grusinskaya finds herself attracted to him.
Grusinskaya departs for the train station, fully expecting to find the Baron waiting for her there. Meanwhile, Kringelein offers to take care of Flaemmchen, who suggests they go to Paris and seek a cure for his illness. As they leave the hotel, Doctor Otternschlag once again observes, “Grand Hotel. People come and go. Nothing ever happens,” although a great deal has.