- Directors: Lawrence Guterman
- Producers: Erica Huggins Scott Kroopf Toby Emmerich Beau Marks Mike Richardson Michele Weiss
- Writers: Lance Khazei
- Genres: Adventure, Comedy, Family, Fantasy
- Actors: Jamie Kennedy Alan Cumming Traylor Howard Steven Wright Kal Penn Bob Hoskins
Ten years after the adventures of Stanley Ipkiss, who does not appear in this film, Dr. Aurthur Neuman (Ben Stein) is giving a tour of the hall of Norse Mythology in Edge City Museum. A man in black comes in to view the hall. When Dr. Neuman reaches the part concerning Loki’s imprisonment, the stranger becomes very angry and transforms, revealing himself to be Loki (Alan Cumming). The tourists panic and flee, but Dr. Neuman stays to argue with the angry god. Loki takes his mask, but realizes it is a fake. In anger he removes Dr. Neuman’s still talking face from his body and puts it on the mask’s stand before getting rid of the guards and storming out of the museum in a whirlwind of rage.
In a town called Fridge City, Tim Avery (Jamie Kennedy), an aspiring cartoonist at an animation company, is feeling reluctant to become a father. He has a beautiful wife, Tonya (Traylor Howard), and a best friend, Jorge (Kal Penn), who is very shy around women. Tim has a close relationship with his dog Otis, who finds an ancient mask in a faroff creek and brings it to his owner’s house.
Tim then comes back to work, with a great idea for a cartoon: A baby and a dog competing for Dad’s attention. At the end, Tonya reveals that she is pregnant again.