- Directors: Eli Roth
- Producers: Evan Astrowsky, Sam Froelich, Lauren Moews, Jeff Hoffman, Eli Roth
- Writers: Eli Roth, Randy Pearlstein
- Genres: Horror, Thriller
- Actors: Rider Strong, Jordan Ladd, James DeBello, Cerina Vincent, Joey Kern, Jeff Hoffman
A man is walking along in the woods, and comes upon a dog that he believes is sleeping. After poking him a few times, he pulls the dog up, and notices that his flesh is rotted out. The scene turns to five college friends, Jeff, Marcy, Paul, Karen, and Bert, who have rented a cabin in the woods. Along the way, they stop at a local convenient store for food, and already notice odd things about the town. For starters, Paul sits on the bench next to a quiet young boy, and as he tries to make small talk, the boy bites him on the hand. To make things worse, the store owner appears to be a very racist individual.
When they arrive at the cabin, Jeff and Marcy immediately retire to their bedroom, Paul and Karen go for a swim in the lake, and Bert goes hunting for squirrels in the woods. He accidentally shoots the man from the beginning of the film during this activity, who he mistakened for a squirrel. The man’s face has become horribly rotted. Scared, Burt shoots at him to keep him away, and he runs back to the cabin. All then seems to go well for awhile. They build a bonfire and trade stories around. They soon encounter a local college kid named Grim who approaches them with his dog, Dr. Mambo. Though a little eccentric, they allow him to join. However, it starts raining, he leaves to take care of his camping equipment, and the group retreats into the house. Awhile later, they hear a knocking at the door, and discover it’s the diseased man that Bert shot before. Desperate for help, the hermit comes after the group. He tries to drive away in their car with Bert shooting his gun, and ends up vomiting blood all over the windshield and the seats. When trying to approach Paul, Marcy and Karen, Paul sets him on fire, and he runs wildly back into the woods.
The film ends with the cops at the country store buying hand-squeezed lemonade from local children outside, using the contaminated water, and thus foreshadowing another, and more widespread, outbreak of the disease. The very last scene is a drinking water truck driving away from the town, ominously.