- Directors: Juan Carlos Fresnadillo
- Producers: Andrew Macdonald, Allon Reich, Enrique Lopez Lavigne, Co Producer, Bernard Bellew, Executive Producer, Danny Boyle, Alex Garland
- Writers: Juan Carlos Fresnadillo, Enrique Lopez Lavigne, Rowan Joffe
- Genres: Action, Horror, Sci-Fi, Thriller
- Actors: Robert Carlyle, Rose Byrne, Jeremy Renner, Catherine McCormack, Imogen Poots, Mackintosh Muggleton, Harold Perrineau, Idris Elba
Don (Robert Carlyle) and his wife Alice (Catherine McCormack) live in a barricaded cottage they share with four others, somewhere in rural Great Britain. They let a terrified boy inside, and moments later, a pack of the infected attack and enter the house. Alice refuses to leave without the boy; Don abandons Alice and escapes as the sole survivor.
Over the course of 28 weeks following the original outbreak, the infected have all starved to death and Britain has been declared relatively safe. An American-led NATO force, under the command of United States Army Brigadier General Stone (Idris Elba), begins repopulating the country. Amongst the new population are Tammy (Imogen Poots) and Andy (Mackintosh Muggleton), Don and Alice’s children, who were in Spain during the initial outbreak. During their subsequent medical inspection, Major Scarlet Ross (Rose Byrne), chief medical officer of District 1, notes Andy’s differently coloured eyes, a trait inherited from his mother. They are subsequently admitted to District 1, a heavily guarded zone of London on the Isle of Dogs guarded by the US Army. Sergeant Doyle (Jeremy Renner), and his friend, Flynn (Harold Perrineau), a helicopter pilot, are amongst the military presence charged with guarding District 1. The children are reunited with their father who is now head caretaker of the district.
28 days pass. Calls for help and screams can be heard over the radio of Flynn’s now abandoned helicopter. A swarm of infected are shown sprinting through a subway exit. As they run into the open, the Eiffel Tower comes into view, revealing that the Rage virus has spread to mainland Europe.