- Directors: Steve Rombough, Anna McRoberts
- Producers: Robert Vince, Anna McRoberts
- Writers: Robert Vince, Anna McRoberts
- Genres: Adventure, Family
- Actors: Jason Earles, Diedrich Bader, Lochlyn Munro, Bill Fagerbakke, Kevin Weisman, Ali Hillis, C Ernst Harth, Chris Gauthier, Quinn Lord
The Buddies (Field Cate, Liliana Mumy, Josh Flitter, Skyler Gisondo, Henry Hodges) sneak aboard the experimental space shuttle Vision 1. The Buddies take a close look around until they are sealed into the shuttle, which is controlled remotely by Astro at mission control for its first flight.
While on the Vision 1, the third tank of gas was never filled. In an effort to refuel, they come across the old R.R.S.S. (Russian Research Space Station), finding a cosmonaut, named Yuri (Diedrich Bader), and his dog Spudnick (Jason Earles) that are stationed there. The cosmonaut is quite content to stay in space, yet the dog wishes to go home. The buddies aboard the R.R.S.S. and the mission control center thought Yuri was crazy (For saying “Puppy Puppies”). As the gas pipe was leaking, Spudnick and The Buddies escape from the R.R.S.S. while Yuri used the Cosmo-pod.
The Vision 1 shows the coordinates of going to the moon. Soon after, the Vision 1 approaches and lands on the moon. They soon begin to walk around. The kids that take care of the buddies find out after a night-time search. They meet a ferret named Gravity (Amy Sedaris), who is the Buddies’ mission control. Gravity orders The Buddies to get back on the Spaceship, in order to circle the back-side of the moon.
Pi awards The Buddies wings of true heroism, then calls them “Space Buddies.” The Buddies then talk about what they remember (for example Budderball was taught how to eat his vegetables). The film ends with Spudnick saying, “It is the journey and friendship that matters the most.” After, the moon is zoomed in with text saying “THE END”