- Directors: Betty Thomas
- Producers: Ross Bagdasarian Jr, Janice Karman
- Writers: Jonathan Aibel, Jon Vitti, Will McRobb, Chris Viscardi, Glenn Berger
- Genres: Animation, Comedy, Family
- Actors: Jason Lee, David Cross, Cameron Richardson, Zachary Levi, Justin Long, Matthew Gray Gubler, Jesse McCartney, Anna Faris, Christina Applegate, Amy Poehler
During the Chipmunks’ concert, David Seville (Jason Lee) suffers a severe injury and is rushed to the hospital. Although he survives, he must stay for a few days to recuperate. Prior to the event, he had made arrangements for Alvin (Justin Long), Simon (Matthew Gray Gubler), and Theodore (Jesse McCartney) to attend school. Little does he know, while in school, the Chipmunks feel like “Chipmunks Out of Water” on account of all the human students around. Meanwhile, Ian Hawke (David Cross) (after the departure of the Chipmunks dealt him a serious blow) searches the world for animals who can sing and dance. He happens upon Brittany (Anna Faris), Jeanette (Christina Applegate), and Eleanor (Amy Poehler), the Chipettes, and cannot wait to make them famous, and get his sworn revenge on the Chipmunks.