- Directors: Troy Duffy
- Producers: Elie Samaha, Lloyd Segan, Robert Fried, Chris Brinker
- Writers: Troy Duffy
- Genres: Action, Crime, Drama, Thriller
- Actors: Willem Dafoe, Sean Patrick Flanery, Norman Reedus, David Della Rocco, Billy Connolly
The film opens with Irish fraternal twins Connor (Sean Patrick Flanery) and Murphy (Norman Reedus) MacManus attending Mass at a Catholic church. Next, (the film is chronologically unclear) while celebrating St. Patrick’s Day with friends, the two get into a bar brawl with three Russian mobsters, who receive a sound beating. The morning after, two of the Russians seek revenge on Connor and Murphy, who kill their attackers in self-defense.
FBI Special Agent Paul Smecker (Willem Dafoe) is assigned to the case and surmises that the death of the Russians was not a professional hit, but probable self-defense. The brothers decide to clear their names and arrive at the police station, where they find that the police and local news reporters see them as heroes. To avoid press attention the brothers decide to spend the night in a holding cell, where they receive an apparent vision from God telling them to hunt down wicked men so that the innocent will flourish.
Connor and Murphy resolve to rid Boston of “evil men”, with their friend and former mob errand boy Rocco (David Della Rocco) eventually joining them to help. Connor learns of a meeting of Russian syndicate bosses at a hotel from a pager taken from one of the dead Russian mobsters and the brothers quickly kill nine bosses and underbossesâ€”saving the leader â€” later referred to as “Fat/Fag Man” for last. They recite their family prayer and kill him with two gunshots to the back of the head â€” the bullets cross and go out his eyes. They place coins on the eyes of all nine bodies, as if to pay the toll to cross the river Styx.
Papa Joe is sent to trial and though there seems to be enough evidence to convict him, the reporters on-scene anticipate his acquittal due to his “Gotti-esque” demeanor. The brothers and Il Duce, aided by Agent Smecker, infiltrate the trial and make a speech stating that they intend to eradicate evil wherever they find it before the three men recite their family prayer and kill Papa Joe, causing panic in the court room. The media dubs the three “Saints”, and the movie ends with various candid interviews of with the public, reflecting on the question “Are the Saints ultimately good, or evil?”