- Directors: Mark Neveldine, Brian Taylor
- Producers: Michael Paseornek, Tom Rosenberg, Gary Lucchesi, Skip Williamson, Richard Wright, David Rubin
- Writers: Mark Neveldine, Brian Taylor
- Genres: Action
- Actors: Jason Statham, Amy Smart
The film opens with a sequence designed to look like a classic video game, depicting Chev Chelios’ (Jason Statham) fall from a helicopter during the final moments of the original Crank. Immediately after his fall, he is scooped off the street via snow shovel by group of Chinese medics and removed from the scene.
He wakes up in a makeshift hospital and sees doctors removing his heart while Johnny Vang (Art Hsu) watches. The doctors place Chev’s heart in a red cooler with a padlock, and place a clear plastic artificial heart in his chest. Chev passes out. He wakes up, and escapes. He notices a yellow battery pack is attached to him. After a gunfight and the interrogation of a thug, Chev learns the location of Johnny Vang – the Cypress Social Club.
Chev calls Doc Miles (Dwight Yoakam), who tells him that he has been fitted with an AbioCor Artificial heart. Once the external battery pack runs out, the internal battery will kick in and he will have one hour before it stops working. He crashes his car in the middle of the conversation, destroying his external battery pack. In order to keep going, Chev has the driver use his jumper cables on himself, and runs to the Club.
During the first part of the credits, Doc Miles places Chev’s heart back in (although we don’t see what he does with Poon Dong) while Eve watches (due to the fire, Chev is covered in full-body bandages). At first, it looks like a failure, but after everyone leaves, Chev’s eyes open, and his heart is heard beating leaving the door open for a sequel.