- Directors: Stephen Herek
- Producers: John Hughes
- Writers: John Hughes
- Genres: Family, Comedy, Adventure
- Actors: Glenn Close, Jeff Daniels, Joely Richardson, Joan Plowright, Hugh Laurie
Roger Dearly (Jeff Daniels) is an American computer game designer, who shares his home in London with his pet dalmatian, Pongo. One day Roger takes Pongo for a walk, and the dog sets his eyes on a beautiful female Dalmatian named Perdy. After a frantic chase through the streets of London, Roger and Pongo discover Perdy likes Pongo; and Perdy’s owner, fashion designer Anita Campbell-Green (Joely Richardson), is taken with Roger when they meet in St. James Park. Romance blossoms between both human and canine couples and Roger and Anita walk down the aisle. Anita works for Cruella de Vil (Glenn Close), a sexy fashion maven with a great love for cigarettes and fur.
Anita becomes inspired by her dogs and designs a fur coat made with spotted fur, causing Cruella to leap on the idea of making garments out of actual Dalmatians. When Cruella learns that Perdy has given birth to fifteen Dalmatian puppies she offers the couple a decent price for the newborn puppies, but the couple refuses. Flying into a maniacal rage, she fires Anita and vows to get even. She has her henchmen, Jasper and Horace (Hugh Laurie & Mark Williams), steal the puppies and deliver them to her ancient estate, De Vil Manor.
Roger designs a successful video game featuring dalmatian puppies as the protagonist and Cruella as the villain, and they move to the English countryside with their millions.