- Directors: Jason Friedberg, Aaron Seltzer
- Producers: Jason Friedberg, Aaron Seltzer, Peter Safran
- Writers: Jason Friedberg, Aaron Seltzer
- Genres: Comedy
- Actors: Matt Lanter, Vanessa Minnillo, Nicole Parker, Crista Flanagan, Gary G Thang Johnson, Kim Kardashian, Ike Barinholtz, Carmen Electra
The movie opens with a shot spoofing the one in Armageddon. In the year 10,001 B.C., a caveman (Will) runs away from a mammoth before getting in a fight with Wolf (Ike Barinholtz). He then encounters a saber-toothed, gasoline-drinking Amy Winehouse (Nicole Parker), who informs him that the world will end on August 29, 2008 (which was the film’s opening day and Michael Jackson’s 50th birthday), revealing their fate laying in a crystal skull. The film flash-forwards to the present, where Will (Matt Lanter), the protagonist, apparently dreamt the past sequence. He then finds out that his girlfriend, Amy (Vanessa Minnillo), is having an affair with Flavor Flav (Abe Spigner) and the two broke up with Will not admiting his true feelings for her.
Later that day, Will has a “Sweet Sixteen” party at his house, despite the fact that he’s 25. Among the guests are Juney (Crista Flanagan) and Will’s best friend Calvin (Gary “G-Thang” Johnson), who attempts to curve a bullet around the room to stop Seth and McLover (Noah Harpster and Austin Scott) from stealing the alcohol, accidentally killing Dr. Phil (John Di Domenico), Anton Chigurh (Barinholtz), and the Beautiful Assassin (Carmen Electra) in the process. By then, Amy arrives with her new boyfriend, an underwear model (Nick Steele), before the High School Musical-like number “Friends Forever” is performed with cameos by an off-key Jessica Simpson (Parker) and Justin Timberlake (Jonas Neal).
Meanwhile, Will and Amy run into Beowulf (Barinholtz), who fights Will in the nude. After Beowulf is defeated, Will and Amy meet Will’s father (Tony Cox) and Will returns the Crystal Skull to its altar, averting further destruction. The film ends with a wedding ceremony for Will and Amy being performed by The Guru Shitka (John Di Domenico), who tries to get Amy to “tickle his pickle”. Then all the characters come back to life and sing a song about dating each other (“Disaster Movie Date Song”), ending with the chipmunks being crushed by yet another cow.